How is P53 inactivated? Human Papilloma virus?????

by Rachel on May 20, 2010

My teacher told us in understanding this information but I do: How p53 is inactivated? A = average human papillomavirus genital warts, cervical cancer does that mean that the only way made for P53 to be inactive when the genital warts and cancer of the cervix. . . . . . ?????

{ 2 comments… read them below or add one }

alexjcharlton May 20, 2010 at 11:29 am

Human papilloma virus’ (HPV) cause many diseased ranging from benign warts (genital and other) up to cancers.

HPV blocks p53 activity in the cell through the expression of it’s gene products. This effective knockout of p53 will lead to uncontrolled cell division and possibly the development of a tumour.

It is important to note that infection with HPV is only one of a huge number of ways in which p53 can be stopped from doing it’s job.

The most common way of blocking p53 is through mutation within the cellular DNA. As cells divide unavoidable mutations occur in the DNA, most of the time such mutations are detected and corrected however occasionally some slip through the net.
If the p53 gene is damaged p53 will be unable to perform it’s function, which may often lead to tumour development.

Other viruses (especially retroviruses like HIV) may damage the p53 gene, or alternatively the gene may be damaged through exposure to carcinogens (cancer causing chemicals.)

vpeng321 May 20, 2010 at 12:16 pm

Got this off of wikipedia lol:
Certain pathogens can also affect the p53 protein that the TP53 gene expresses. One such example, the Human papillomavirus (HPV), encodes for a protein, E6, which binds the p53 protein and inactivates it.

Leave a Comment

Previous post:

Next post: