How long does it take for dysplasia to occur after a woman comes into contact with HPV?

by Rachel on July 29, 2011

{ 2 comments… read them below or add one }

Gumdrop Girl July 29, 2011 at 7:25 pm

It varies on a lot of factors. Sometimes dysplasia doesn’t occur. Sometimes it shows up in a matter of weeks. Sometimes it takes up to 3 years to develop.

If you are sexually active, not pregnant and are under the age of 27, you might want to ask your doctor about Gardasil. It’s the vaccine that protects you against 4 strains of HPV. Even if you may have contracted one type, you probably haven’t caught the others.

tarnishedsilverheart July 29, 2011 at 8:03 pm

It make take years for abnormal cervical cells to develop.

The vaccine may not be cost for the gal in her mid twenties…the vaccine works best when given before any sexual contact. If you decide to consider the vaccine make sure that your insurance company will cover the cost of the vaccine…and each state has different guideline of how they cover the vaccine. The vaccine only prevent 4 HPV types two low risk HPV types 6 and 11 and two high risk HPV types 16 and 18.

Articles follow:
UAB Researchers Make Breakthrough Discovery of HPV ReplicationPosted on March 15, 2004 at 4:00 p.m.

UAB Researchers have discovered the mechanism used by a common virus to replicate and remain in the human body for decades. Human papillomavirus (HPV), a family of over 100-related viruses, are responsible for a variety of medical conditions, ranging from benign hand or foot warts to genital warts, cervical cancer and recurrent respiratory papillomatosis, a potentially fatal disease in children.

In an article published in the Proceedings of the National Academy of Sciences in March, the research team reports that a viral replication protein known as E2 binds the circular viral DNA to cell structures called spindle fibers that are present in a cell when it divides, a process known as mitosis. In mitosis, a single cell divides in two, creating two genetically identical daughter cells. By latching onto the spindle fibers of the cell as it divides, HPV DNA also divides and replicates itself in each of the new daughter cells where it can continue to replicate and persist indefinitely.

“In effect, HPV is able to mimic our own chromosomes, behaving as a sort of ‘mini-chromosome’, independently replicating and keeping pace as the cellular chromosomes replicate and the cell divides,” says Tom Broker, PhD, professor of biochemistry and molecular genetics and co-author of the paper. “This allows the virus to remain in our bodies indefinitely, with the potential of causing serious disease years, even decades, after first exposure.”

Broker says that virtually all humans carry at least one type of HPV for much of their lives, usually transmitted to the external skin very early in life or to the internal mucosal lining later during sexual contact. For most people, the virus persists at low levels without causing obvious disease, and the body’s immune system keeps it in check.

However, in some people, the virus can become activated and cause lesions, particularly if the infected tissue is repeatedly injured, or following periods of emotional or physical stress, during pregnancy, as a result of immunosuppressive therapy for immune disorders or organ transplantation, as a outcome of progressing HIV/AIDS, and even as a consequence of aging.

“This is a major breakthrough in our quest to find ways to treat the myriad conditions associated with HPV,” says Louise Chow, PhD, professor of biochemistry and molecular genetics and co-author of the paper. “This improves our understanding of the mechanisms the virus uses to reproduce. We now have new molecular targets to aim at for antiviral drug discovery.”

HPV’s special mechanism for attaching itself to the mitotic spindles and getting pulled into the daughter cells has not been observed with other families of viruses, according to Chow.

There are about 15,000 new cases of cervical or penile cancer attributed to HPV each year in the US, and nearly 5000 deaths. Worldwide, 600,000 cases occur annually, especially in developing countries without advanced medical diagnostic methods such as Papanicolaou smear screening, which can detect the activation of HPV early enough for aggressive treatment to be successful.

HPV infection in the throat and respiratory tract, laryngeal papillomatosis, can cause recurrent respiratory papillomatosis in children, who are usually infected at birth from contact with HPV-caused genital warts present in the mother. There are an estimated 2,000 cases per year in the United States

This research was funded by grants from the United States Public Health Service and the National Cancer Institute, one of the National Institutes of Health. Tom Broker is the President of the International Papillomavirus Society. More information on HPV and associated disease can be found at the society’s web site at http://www.IPVSoc.org

Study Examines Cost-Effectiveness Of HPV Vaccine
22 Aug 2008

The cost of administering human papillomavirus vaccines is justified in pre-adolescent girls but becomes less so as the age of women receiving the injection increases, according to a study published Thursday in the New England Journal of Medicine, the Wall Street Journal reports. In clinical trials, the vaccines have been shown to be 100% effective in preventing infection with HPV strains 16 and 18, which together cause about 70% of cervical cancer cases (Loftus, Wall Street Journal, 8/21). FDA in July 2006 approved Merck’s HPV vaccine Gardasil for sale and marke

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