Is there any history that Imiquimod (Aldara) actually helped anyone with an HPV infection?

by Rachel on April 16, 2011

In other words has it helped any ones immune system to help them fight off the infection? Is there any history that someones fought the infection.

{ 3 comments… read them below or add one }

Mara April 16, 2011 at 6:19 pm

I got prescribed aldara and used it for a bit bit was such a huge hassle i hated having to put it on, after a little bit my warts cleared all by themselves =]

tarnishedsilverheart April 16, 2011 at 6:36 pm

Aldara is commonly prescribed for visible genital warts. Aldara works with the immune system. I know of several women who have used Aldara for VIN. I am owner of a gynecological cancer site…

I wish I could say that I personally have used Aldara…but I can’t…when my VIN (C(S) was diagnosed my doctor recommend 5 FU after removing the lesion. I didn’t have genital warts.

Aldara can have some might strong side effects…so you must be prepared for them…and understand how to minimize them.

The Aldara site has some good information…but this article may also interest you…remember vulva dysplasia is pretty rare and studies have been small but studies and what I have seen over the years does support using Aldara.

Vulvar Dysplasia and Carcinoma
Patient Medical Areas

Graceway Pharmaceuticals released positive results from a phase III trial of Aldara for the treatment of Vulvar intraepithelial neoplasia (VIN). This randomized study enrolled fifty-two subjects with grade 2 or 3 VIN lesions. The subjects received Aldara Cream (5%) or placebo cream applied to lesions twice a week for sixteen weeks. The primary endpoint was a reduction in lesion size of more than 25% four weeks after the end of treatment (twenty weeks after the beginning of treatment). This endpoint was reached by 81% of subjects treated with Aldara and in none of the subjects treated with placebo (P less than .001). Lesions were completely cleared in 34% of the Aldara group and an additional 19% of the subjects experienced a reduction in lesion size greater than 75%. All nine subjects who were completely clear at twenty weeks remained clear at twelve months. Four of these nine subjects had two or three surgeries for VIN before being treated with Aldara. Secondary endpoints included histologic regression from grade 2 or 3 VIN to a lower grade, clearance of human papillomavirus (HPV) and relief of clinical symptoms at twenty weeks and twelve months. Histologic regression from grade 2 or 3 to a lower grade occurred in 69% of subjects treated with Aldara and 4% of those treated with placebo (P less than .001). Complete histologic clearance was reported in eight Aldara-treated patients. Histologic regression was strongly associated with viral clearance (P less than .001). At twenty weeks, HPV was completely cleared in seventeen lesions; fifteen after treatment with Aldara and two after treatment with placebo. A significant reduction in itching and pain was reported in the Aldara-treated arm versus those treated with placebo at twenty weeks (P=.008 and P=.004, respectively) and at twelve months (P=.04 and P=.02, respectively). There was no significant difference between treatment groups on self-reported, health-related quality of life, body image, or sexuality at either time point. Based on the results Graceway plans to continue with the development of Aldara for this indication.

http://www.medicine.mcgill.ca/oncology/pubs/Gotlieb/Gotlieb_2007_04_HPV-Related-Vulvar.pdf

JusTmE April 16, 2011 at 7:27 pm

If you use Aldara the way it is supposed to be used and stick with it, it should get rid of the warts. It doesn’t boost your immune system or anything, it just gets rid of visible warts. Usually, if you get rid of them they probably won’t come back because our bodies usually fight them off on its own. If you are wanting to maybe give your immune system a boost, think about taking vitamins once a day.

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