Pathology of Genital Warts

by Rachel on July 27, 2010

HPVs are nonenveloped double-stranded DNA viruses. The HPV genome encodes six open reading frames in early (E1, E2, E4, E5, E6, E7) and two open reading frames of late (L1, L2). Define the differences in the subtypes of HPV L1. The genes encode proteins regulating function E, and genes coding for viral L protein capsid.

Malignant tumors develop after long latency periods during which additional cellular changes occur in infected cells. The region at the beginning of these HPV types encodes two oncoproteins E6 and E7, which associate with and neutralize the p53 tumor suppressor cells and retinoblastoma (pRb), respectively. The virus infects the basal layer and the first of its life cycle is linked to the progressive differentiation of epithelial cells.

More than 120 different subtypes of HPV have been identified. Of the 120 subtypes of HPV, 30 infect the genital epithelium. Making the HPV subtype determines the probability of malignant transformation, but has no effect on the diagnosis or treatment of genital warts. These subtypes can be induced in three categories on their cancer and dysplasia probability divided.

HPV types 6 and 11 are considered low risk and are the most common cause of genital warts. HPV types 31, 33, 45, 51, 52, 56, 58 and 59 are medium risk, because they are frequent causes of squamous intraepithelial neoplasia, but less common causes of squamous cell carcinoma. HPV types 16 and 18 are solid with cervical dysplasia and anogenital cancer. Patients have visible genital warts can be infected by several types of HPV.

the genetic basis of the category of risk HPV. Proteins E6 and E7 HPV low risk types HPV 6 and 11 as an episome and rarely incorporate replicate their genetic material into the host DNA, although these proteins have been detected occasionally in cancer cells . Intermediate and high risk HPV DNA inserts itself into human DNA. can produce your genes E6 and E7, which alter cell growth regulation oncoproteins. oncoprotein E6 inactivates p53, the tumor suppressor gene. E7 oncoprotein pRb inactivation by product.

The immune system plays a central role in the regression of HPV-related genital diseases of both humoral and cellular immunity. Spontaneous regression of genital warts show significant epidermal and dermal influx of CD4 lymphocytes from the memory activated nonregressing lesions. Cellular immunity seems to be the first choice for defense against infection with HPV.

The association of antibodies against proteins of HPV-serum with the HPV-related disease is well documented, but what is the role of these antibodies is uncertain, since their presence is not correlated with wart clearance. Evidence that the T cells in the epithelium of male and female genitals secrete protective antibodies against many HPV infections, the importance of this lack of clarity.

Genital warts are almost by sexual contact, but vertical transmission and spread Autoinoculation occur only rarely. About 70 percent of people who have sexual contact with an infected genital warts. The incubation period for HPV ranges from three weeks to eight months, with an average of 2-3 months after initial contact.

The rate of subclinical infection is as high as 40 percent if measured by polymerase chain reaction DNA analysis on the skin of the genitals. After the first clinical manifestation, the warts may grow in number and size, or may regress spontaneously (as many as 30% over four months). The share of long-term regression is unknown.

Even with treatment, is found in the three months to 25-67 percent of cases. Relapses are often due to genital warts previous sites, a long-term cell at the site of prior approval, then reactivate. Infection with HPV high-risk and older people are risk factors for persistence.

Traditional theories postulated that once a person is infected, HPV remains in the body for a lifetime. However, recent studies using sensitive DNA techniques showed that treatment suppressed against HPV (the virus that can be measured at levels below PCR) is possible by the immunological reaction.

These studies concluded that, among other things, the treatment of genital warts, HPVCurative best extracts “inhibited skin papillomas (HPV) and a decreased conversion of papillomas to carcinomas, in which” significant apoptosis (resolution) of the test HPV DNA in the cells without damaging surrounding healthy tissue resulted.

HPVCurative contains strictly certified organic plant extracts anti-viral drugs that destroy the capacity of the virus genital warts (HPV). The extracts are harvested and distilled by hand for medical use – they are pure and complete. This is important in the preparation of treatment against HPV, and it is of crucial importance when applying any of the genitals. For more information, visit http://www. bcured. net.

Employees of Nature Power Company, a network dedicated to the promotion of client websites and software development. You can visit the following sites to learn more about our natural organic products. http://www. bcured. net http://www. Pharma nature. org

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